Years after X-Men: Days of Future Past, the world has fewer mutants in it. An evil organization ran by Nathanial Essex is after a girl, Laura, who was cloned from Logan's DNA. It is up to Logan and Charles Xavier to try to protect Laura from Essex and his plan to destroy the world. Yet, Wolverine's healing abilities no longer work as well as in his youth. Professor X's abilities and memories have begun to fail as well with the onset of Alzheimer's disease. Can these heroes and friends rise up one last time to save a mutant in need?