The loveable Mogwai Gizmo, and his feckless owner Billy Peltzer, return for another go-round with his mischievous and sinister offspring. This time, while living in New York City, Gizmo is exposed to water inside the high-tech skyscraper where his owner works. The devious monsters take over the building, wreaking havoc on it's occupants and it's highly automated systems. With a hyper-intelligent leader, aptly named "Brain," the army of malevolent Gremlins seek to first control the building before moving outside to overrun the city. Gizmo and Billy, with the help of Billy's technology-obsessed boss, fight valiantly to contain the horde and regain control of the building thereby preventing the escape of the evil creatures and saving the city from destruction.