Matt Kowalsky is a charismatic, witty astronaut who enjoys entertaining his crew. He plans on going on one last space mission with medical engineer Ryan Stone before he retires. During their space walk, their worlds are turned upside down when rubbish strikes the area where they're working. Their shuttle is destroyed, and Ryan and Matt are left aimlessly floating in space. Both of them are desperately struggling to fix this devastating situation before it's too late. During all this chaos, Ryan also struggles with a complicated past that has her pondering giving up completely.